{"product_id":"cardiogen-research-peptide","title":"Cardiogen","description":"\u003cp\u003e\u003cstrong\u003eCertificate of Analysis (COA): See Images\u003c\/strong\u003e\u003c\/p\u003e\n\u003cp\u003e\u003cstrong\u003eCardiogen (Ala-Glu-Asp-Arg)\u003c\/strong\u003e is a synthetic tetrapeptide that has drawn research attention for an unusual reason: its apparent effect on the structural proteins that give a cell its shape. One of the smaller members of the Khavinson bioregulator family, Cardiogen has been studied in cardiac-derived cell systems for its reported influence on cytoskeletal and nuclear-matrix protein synthesis, cell proliferation, and apoptosis-related signalling. While not approved for human or veterinary use, it is used in laboratory and academic research as a model organ-specific short peptide.\u003c\/p\u003e\n\u003ch3\u003eResearch Applications\u003c\/h3\u003e\n\u003cp\u003eThe published literature on Cardiogen, drawn almost entirely from preclinical cell-culture and animal studies, centres on a few recurring themes:\u003c\/p\u003e\n\u003cul\u003e\n\u003cli\u003e\n\u003cstrong\u003eCytoskeletal \u0026amp; Nuclear-Matrix Proteins:\u003c\/strong\u003e In cultured fibroblasts, Cardiogen has been reported to increase the expression of cytoskeletal proteins (actin, tubulin, vimentin) and nuclear-matrix proteins (lamin A and lamin C), the structural scaffolding of the cell.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eCardiomyocyte Proliferation:\u003c\/strong\u003e In myocardial tissue cultures from young and aged rats, the peptide has been studied for its stimulating effect on cell proliferation, assessed using markers such as Ki-67, with the effect notable in aged tissue.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eApoptosis Signalling:\u003c\/strong\u003e Research has examined Cardiogen's reported association with reduced p53 protein expression in myocardial cell models, a pathway linked to programmed cell death.\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003cp\u003eWhat makes Cardiogen of particular interest to researchers is the proposed link between these threads: that by promoting structural-protein synthesis, the peptide may influence cell proliferation and survival at the same time. Its molecular identity and structure are catalogued in the \u003ca href=\"https:\/\/pubchem.ncbi.nlm.nih.gov\/compound\/11583989\" rel=\"noopener\" target=\"_blank\"\u003eNIH PubChem database\u003c\/a\u003e, and it is commonly studied in parallel with other Khavinson bioregulators such as \u003ca href=\"https:\/\/tidelabs.co.uk\/products\/cortagen-research-peptide\"\u003eCortagen\u003c\/a\u003e and \u003ca href=\"https:\/\/tidelabs.co.uk\/products\/pancragen-research-peptide\"\u003ePancragen\u003c\/a\u003e.\u003c\/p\u003e\n\u003ch3\u003eTechnical Information\u003c\/h3\u003e\n\u003cul\u003e\n\u003cli\u003e\n\u003cstrong\u003eChemical Name:\u003c\/strong\u003e L-Alanyl-L-α-glutamyl-L-α-aspartyl-L-arginine\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eSynonyms:\u003c\/strong\u003e AEDR, H-Ala-Glu-Asp-Arg-OH, Cardiogen\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eMolecular Formula:\u003c\/strong\u003e C₁₈H₃₁N₇O₉\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eMolecular Weight:\u003c\/strong\u003e 489.5 g\/mol\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eSequence (Amino Acid):\u003c\/strong\u003e Ala-Glu-Asp-Arg (AEDR)\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eCAS Number:\u003c\/strong\u003e Not assigned\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003ePeptide Classification:\u003c\/strong\u003e Synthetic Khavinson organ-specific short peptide bioregulator (tetrapeptide)\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003ch3\u003eStorage Guidelines\u003c\/h3\u003e\n\u003cul\u003e\n\u003cli\u003eLyophilized peptide is stable at room temperature for several weeks.\u003c\/li\u003e\n\u003cli\u003eFor long-term storage, keep at −20°C or below.\u003c\/li\u003e\n\u003cli\u003e\n\u003cmeta charset=\"UTF-8\"\u003e\n\u003cp class=\"p1\"\u003eOnce reconstituted, store at 2–8 °C. Effective use depends on the solution used.\u003c\/p\u003e\n\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003ch3\u003eSolubility\u003c\/h3\u003e\n\u003cp\u003eCardiogen reconstitutes readily in \u003ca href=\"https:\/\/tidelabs.co.uk\/products\/bacteriostatic-water-10ml\"\u003ebacteriostatic water\u003c\/a\u003e and is also reported to dissolve in standard aqueous buffers.\u003c\/p\u003e\n\u003ch3\u003eReferences\u003c\/h3\u003e\n\u003cul\u003e\n\u003cli\u003eChalisova, N. I., Lesniak, V. V., Balykina, N. A., et al. (2009). \"The effect of the amino acids and cardiogen on the development of myocardial tissue culture from young and old rats.\" \u003cem\u003eAdvances in Gerontology\u003c\/em\u003e, 22(3), 409–413. \u003ca rel=\"noopener\" href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/20210190\/\" target=\"_blank\"\u003ehttps:\/\/pubmed.ncbi.nlm.nih.gov\/20210190\/\u003c\/a\u003e\n\u003c\/li\u003e\n\u003cli\u003eKhavinson, V. K., Popovich, I. G., Linkova, N. S., et al. (2021). \"Peptide Regulation of Gene Expression: A Systematic Review.\" \u003cem\u003eMolecules\u003c\/em\u003e, 26(22), 7053. \u003ca rel=\"noopener\" href=\"https:\/\/doi.org\/10.3390\/molecules26227053\" target=\"_blank\"\u003ehttps:\/\/doi.org\/10.3390\/molecules26227053\u003c\/a\u003e\n\u003c\/li\u003e\n\u003cli\u003eKhavinson, V. K., Lin'kova, N. S., \u0026amp; Tarnovskaya, S. I. (2016). \"Short Peptides Regulate Gene Expression.\" \u003cem\u003eBulletin of Experimental Biology and Medicine\u003c\/em\u003e, 162(2), 288–292. \u003ca rel=\"noopener\" href=\"https:\/\/doi.org\/10.1007\/s10517-016-3596-7\" target=\"_blank\"\u003ehttps:\/\/doi.org\/10.1007\/s10517-016-3596-7\u003c\/a\u003e\n\u003c\/li\u003e\n\u003c\/ul\u003e","brand":"Tide Labs","offers":[{"title":"10mg","offer_id":53709548519767,"sku":null,"price":24.99,"currency_code":"GBP","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0941\/3142\/1527\/files\/Cardiogen10mgVial.webp?v=1780589501","url":"https:\/\/tidelabs.co.uk\/products\/cardiogen-research-peptide","provider":"Tide Labs ","version":"1.0","type":"link"}