{"product_id":"pancragen-research-peptide","title":"Pancragen","description":"\u003cp\u003e\u003cstrong\u003eCertificate of Analysis (COA): See Images\u003c\/strong\u003e\u003c\/p\u003e\n\u003cp\u003e\u003cstrong\u003ePancragen (Lys-Glu-Asp-Trp)\u003c\/strong\u003e is a synthetic research tetrapeptide and a pancreas-associated member of the Khavinson family of short peptide bioregulators. Originally derived from a peptide identified in pancreatic tissue, Pancragen has become an exciting subject of study in preclinical research, particularly in areas related to tissue-specific gene expression, pancreatic cell differentiation, and age-associated endocrine function. While not approved for human or veterinary use, Pancragen continues to generate strong interest as a promising candidate in laboratory and academic research settings.\u003c\/p\u003e\n\u003ch3\u003eArea of Interest\u003c\/h3\u003e\n\u003cp\u003eResearch on Pancragen has focused on several areas of interest:\u003c\/p\u003e\n\u003cul\u003e\n\u003cli\u003e\n\u003cstrong\u003eGlucose Tolerance Models:\u003c\/strong\u003e Investigated in preclinical primate studies examining glucose, insulin, and C-peptide responses in aged animals, where reported effects partially persisted for several weeks after administration.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003ePancreatic Cell Differentiation:\u003c\/strong\u003e Examined in human pancreatic cell cultures for its influence on differentiation-associated factors such as CXCL12 and Hoxa3, with effects reported as more pronounced in aged cell models.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eGene Expression Regulation:\u003c\/strong\u003e Studied for its ability to influence tissue-specific transcriptional activity within pancreatic tissue, a defining characteristic of the Khavinson bioregulator family.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eGeroprotective Research:\u003c\/strong\u003e Explored as a low-molecular-weight peptide of interest in studies of age-associated endocrine decline and pancreatic tissue homeostasis.\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003cp\u003eTogether, these studies position Pancragen as a distinctive organ-specific short peptide bioregulator. It is frequently investigated alongside related Khavinson peptides such as \u003ca href=\"https:\/\/tidelabs.co.uk\/products\/epithalon\"\u003eEpithalon\u003c\/a\u003e and \u003ca href=\"https:\/\/tidelabs.co.uk\/products\/pinealon-research-peptide\"\u003ePinealon\u003c\/a\u003e, reflecting its potential as an exciting area of discovery in peptide bioregulation.\u003c\/p\u003e\n\u003ch3\u003eTechnical Information\u003c\/h3\u003e\n\u003cul\u003e\n\u003cli\u003e\n\u003cstrong\u003eChemical Name:\u003c\/strong\u003e L-Lysyl-L-α-glutamyl-L-α-aspartyl-L-tryptophan\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eSynonyms:\u003c\/strong\u003e KEDW, Lys-Glu-Asp-Trp, Pancragen Bioregulator\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eMolecular Formula:\u003c\/strong\u003e C₂₆H₃₆N₆O₉\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eMolecular Weight:\u003c\/strong\u003e 576.6 g\/mol\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eSequence (Amino Acid):\u003c\/strong\u003e Lys-Glu-Asp-Trp (KEDW)\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eCAS Number:\u003c\/strong\u003e Not assigned\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003ePeptide Classification:\u003c\/strong\u003e Synthetic Khavinson organ-specific short peptide bioregulator (tetrapeptide)\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003ch3\u003eStorage Guidelines\u003c\/h3\u003e\n\u003cul\u003e\n\u003cli\u003eLyophilized peptide is stable at room temperature for several weeks.\u003c\/li\u003e\n\u003cli\u003eFor long-term storage, keep at −20°C or below.\u003c\/li\u003e\n\u003cli\u003e\n\u003cmeta charset=\"UTF-8\"\u003e\n\u003cp class=\"p1\"\u003eOnce reconstituted, store at 2–8 °C. Effective use depends on the solution used.\u003c\/p\u003e\n\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003ch3\u003eSolubility\u003c\/h3\u003e\n\u003cp\u003ePancragen is soluble in \u003ca href=\"https:\/\/tidelabs.co.uk\/products\/bacteriostatic-water-10ml\"\u003ebacteriostatic water\u003c\/a\u003e and other aqueous buffers depending on purity and formulation.\u003c\/p\u003e\n\u003ch3\u003eReferences\u003c\/h3\u003e\n\u003cul\u003e\n\u003cli\u003eKhavinson, V. K., Gapparov, M. M.-G., Sharanova, N. E., et al. (2010). \"Study of biological activity of Lys-Glu-Asp-Trp-NH₂ endogenous tetrapeptide.\" \u003cem\u003eBulletin of Experimental Biology and Medicine\u003c\/em\u003e, 149(3), 351–353. \u003ca rel=\"noopener\" href=\"https:\/\/doi.org\/10.1007\/s10517-010-0944-x\" target=\"_blank\"\u003ehttps:\/\/doi.org\/10.1007\/s10517-010-0944-x\u003c\/a\u003e\n\u003c\/li\u003e\n\u003cli\u003eGoncharova, N. D., Ivanova, L. G., Oganyan, T. E., et al. (2015). \"Correction of impaired glucose tolerance using tetrapeptide (Pancragen) in old female rhesus monkeys.\" \u003cem\u003eAdvances in Gerontology\u003c\/em\u003e, 28(3), 579–585. \u003ca rel=\"noopener\" href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/28509500\/\" target=\"_blank\"\u003ehttps:\/\/pubmed.ncbi.nlm.nih.gov\/28509500\/\u003c\/a\u003e\n\u003c\/li\u003e\n\u003cli\u003eGoncharova, N. D., Ivanova, L. G., Oganian, T. E., et al. (2014). \"Impact of tetrapeptide pancragen on endocrine function of the pancreas in old monkeys.\" \u003cem\u003eAdvances in Gerontology\u003c\/em\u003e, 27(4), 662–667. \u003ca rel=\"noopener\" href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/25946840\/\" target=\"\"\u003e\u003c\/a\u003e\n\u003c\/li\u003e\n\u003c\/ul\u003e","brand":"Tide Labs","offers":[{"title":"10mg","offer_id":53698910912855,"sku":"TL-PANCRA-10MG","price":48.95,"currency_code":"GBP","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0941\/3142\/1527\/files\/pancragen10mgvial.webp?v=1780491054","url":"https:\/\/tidelabs.co.uk\/products\/pancragen-research-peptide","provider":"Tide Labs ","version":"1.0","type":"link"}