ARA-290 (Cibinetide) is a synthetic 11-amino acid peptide modeled on the helix B surface domain of Erythropoietin (EPO). Unlike EPO, ARA-290 is non-hematopoietic, meaning it does not stimulate red blood cell production. Instead, it is designed to selectively bind to the Innate Repair Receptor (IRR), a heterocomplex consisting of EPO receptors and the beta-common receptor (CD131). Preclinical research identifies the IRR as a molecular switch for tissue protection and anti-inflammatory signaling. By activating this pathway, ARA-290 is investigated for its potential to reduce inflammation and promote nerve repair without the cardiovascular side effects associated with systemic EPO administration. Supplied as a lyophilized powder strictly for laboratory research.

Area of Interest

Research on ARA-290 has focused on neuroprotection and autoimmune pathways:

• Small Fiber Neuropathy (SFN): Extensively studied in models of sarcoidosis and diabetes for its potential to promote the regeneration of small nerve fibers and modulate neuropathic pain signaling.
• Innate Repair Receptor (IRR) Agonism: Investigated for its ability to downregulate pro-inflammatory cytokines (TNF-alpha) specifically in tissues undergoing stress or damage.
• Metabolic & Cardiac Health: Research explores its cytoprotective role in ischemia-reperfusion models and its influence on insulin sensitivity via anti-inflammatory mechanisms.
• Immunomodulation: Studies examine its utility in dampening the pathological immune response in autoimmune frameworks without suppressing the entire immune system.

These properties make ARA-290 a primary reagent for laboratories investigating neuropathic pathology, chronic inflammation, and the non-hematopoietic functions of the EPO pathway.

Technical Information

• Chemical Name: Cibinetide (ARA-290)
• Synonyms: Pyroglutamate Helix B Surface Peptide
• Molecular Formula: C₅₁H₈₄N₁₆O₂₁
• Molecular Weight: 1257.3 g/mol
• Sequence: pGlu-Glu-Val-Ser-Glu-Frp-Gln-Val-Leu-Ser-Leu-OH (Pyroglutamated N-terminus)
• Mechanism: Innate Repair Receptor (IRR) Selective Agonist
• Peptide Classification: EPO-derivative (Non-hematopoietic)

Storage Guidelines

• Lyophilized peptide is stable at room temperature for several weeks.
• For long-term storage, keep at −20°C or below.

• Once reconstituted, store at 2–8 °C. Use within 2-3 weeks.

Solubility

ARA-290 is soluble in sterile water or saline. It is a stable peptide that reconstitutes easily.

References

• Brines, M., et al. (2004). “Erythropoietin mediates tissue protection through an erythropoietin and common beta-subunit heteroreceptor.” Proceedings of the National Academy of Sciences. https://doi.org/10.1073/pnas.0406491101
• Heij, L., et al. (2012). “Safety and efficacy of ARA 290 in sarcoidosis patients with symptoms of small fiber neuropathy: a randomized, double-blind pilot study.” Molecular Medicine, 18, 1430–1436. https://doi.org/10.2119/molmed.2012.00332
• Brines, M., & Cerami, A. (2012). “The innate repair receptor: a multi-level control system of tissue injury.” Flmminology.
• Dahan, A., et al. (2013). “ARA 290 improves symptoms in patients with sarcoidosis-associated small fiber neuropathy and impairs inflammation.” Molecular Medicine.

Certificate of Analysis (COA): Available here