GHGH Fragment 176-191 is a synthetic peptide derived from a specific portion of the human growth hormone (HGH) molecule. Unlike full-length HGH, this fragment is focused on the C-terminal region (amino acids 176–191), which has been shown in preclinical models to influence fat metabolism without the broad hormonal effects associated with HGH itself. This has made HGH Fragment 176-191 a strong area of research interest in weight management, metabolic regulation, and energy expenditure.

Area of Interest

HGH Fragment 176-191 is studied for its selective biological activity in laboratory models:

• Lipolysis (Fat Breakdown): Evidence from preclinical studies suggests stimulation of fat metabolism while avoiding hyperglycemia linked to native HGH.
• Anti-Adipogenic Effects: Investigated for potential to reduce fat accumulation and support metabolic research.
• Metabolic Energy Regulation: Explored for roles in mitochondrial activity and energy expenditure pathways.
• Targeted Activity: Does not appear to affect insulin-like growth factor-1 (IGF-1) levels in the same way as full-length HGH.

Its highly specific action makes HGH Fragment 176-191 a valuable tool in research models studying obesity, metabolic disorders, and fat regulation.

Technical Information

• Chemical Name: Human Growth Hormone Fragment 176-191
• Synonyms: HGH Frag 176-191, AOD9604 fragment, GH 176-191
• Molecular Formula: C₇₈H₁₂₃N₂₃O₂₃S₂
• Molecular Weight: ~1815.08 g/mol
• Sequence (Amino Acid): Tyr-Leu-Arg-Ile-Val-Glu-Gln-Lys-Ala-Phe-Thr-Pro-Ser-Glu-Thr
• CAS Number: 221231-10-3
• Peptide Classification: Synthetic peptide fragment derived from HGH

Storage Guidelines

• Lyophilized powder may be kept at room temperature for short periods.
• For long-term stability, store at −20°C or below.
• Once reconstituted, store at 2–8 °C. Effective use depends on the solution used.
  

Solubility

Soluble in sterile water or appropriate aqueous buffers.

References

• Heffernan, M., et al. (2000). “HGH fragment 177–191 stimulates lipolysis in adipose tissue of obese rodents.” American Journal of Physiology-Endocrinology and Metabolism, 279(5), E1205–E1212. https://doi.org/10.1152/ajpendo.2000.279.5.E1205
• Ng, F. M., et al. (2000). “Metabolic effects of a synthetic fragment of human growth hormone.” Metabolism, 49(11), 1491–1496. https://doi.org/10.1053/meta.2000.17730

Certificate of Analysis (COA): Available here