Sermorelin (GRF 1-29) is a synthetic peptide analogue of the naturally occurring Growth Hormone-Releasing Hormone (GHRH). It corresponds to the amino-terminal segment (first 29 amino acids) of the endogenous 44-amino acid GHRH hormone. Preclinical research identifies Sermorelin as a potent growth hormone secretagogue that stimulates the pituitary gland to secrete Growth Hormone (GH) in a pulsatile manner, mimicking physiological rhythms. Unlike HGH administration which bypasses the feedback loop, Sermorelin is investigated for its ability to preserve the hypothalamic-pituitary-somatotropic axis. Supplied as a lyophilized powder strictly for laboratory research.

Area of Interest

Research on Sermorelin has focused on several critical metabolic and endocrine pathways:

• Somatotropic Signaling: Investigated for its ability to bind to the GHRH receptor on the anterior pituitary, triggering the cAMP signaling pathway to release endogenous Growth Hormone.
• Cellular Senescence & Metabolism: Models examine the downstream effects of increased IGF-1 levels on cellular repair, protein synthesis, and lipolysis (fat metabolism).
• Sleep Architecture: Research explores the link between GHRH stimulation and the regulation of Slow-Wave Sleep (SWS), suggesting a role in sleep-dependent recovery processes.
• Pituitary Function: Used in diagnostic research to evaluate the functional capacity of the pituitary gland to secrete hormones.

These properties make Sermorelin a fundamental reagent for laboratories studying the endocrine system, metabolic rate, and the biology of aging.

Technical Information

• Chemical Name: Sermorelin Acetate (GHRH 1-29)
• Synonyms: GRF 1-29 NH2, Geref
• Molecular Formula: C₁₄₉H₂₄₆N₄₄O₄₂S
• Molecular Weight: 3357.9 g/mol
• Sequence: Tyr-Ala-Asp-Ala-Ile-Phe-Thr-Asn-Ser-Tyr-Arg-Lys-Val-Leu-Gly-Gln-Leu-Ser-Ala-Arg-Lys-Leu-Leu-Gln-Asp-Ile-Met-Ser-Arg-NH2
• CAS Number: 86168-78-7
• Peptide Classification: Growth Hormone-Releasing Hormone (GHRH) Analogue

Storage Guidelines

• Lyophilized peptide is stable at room temperature for several weeks.
• For long-term storage, keep at −20°C or below.

• Once reconstituted, store at 2–8 °C. Effective use depends on the solution used.

Solubility

Sermorelin is soluble in sterile water, saline, or bacteriostatic water. Gentle rotation is recommended for dissolution.

References

• Walker, R. F. (2006). “Sermorelin: a better approach to management of adult-onset growth hormone insufficiency?” Clinical Interventions in Aging, 1(4), 307–308. https://doi.org/10.2147/ciia.2006.1.4.307
• Korpinen, E. L., et al. (1998). “Growth hormone-releasing hormone (1-29) is a potent stimulator of growth hormone release in humans.” Life Sciences.
• Vitiello, M. V., et al. (2000). “Growth hormone releasing hormone improves the sleep of older men.” American Journal of Physiology-Endocrinology and Metabolism.
• Prakash, A., & Goa, K. L. (1999). “Sermorelin: a review of its use in the diagnosis and treatment of growth hormone deficiency.” BioDrugs, 12(2), 139-157. https://doi.org/10.2165/00063030-199912020-00007

Certificate of Analysis (COA): Available here