DSIP (Delta Sleep-Inducing Peptide) is a naturally occurring neuropeptide that has been synthesized for research purposes and investigated for its potential roles in sleep regulation, stress response, and neuroprotection. First identified in the 1970s, DSIP has remained of significant academic interest due to its unique activity in the central nervous system. It is not yet approved for human or veterinary use but continues to be studied as a promising research candidate.

Area of Interest

Research into DSIP has explored several potential areas:

• Sleep Research: Studied in animal and preclinical models for its influence on slow-wave sleep cycles and circadian rhythm regulation.
• Stress & Cortisol Response: Investigated for potential effects on stress adaptation, adrenal function, and cortisol secretion pathways.
• Neuroprotection: Early studies suggest DSIP may play a role in protecting neurons against oxidative stress and ischemic injury models.
• Pain & Recovery Models: Examined for possible modulation of pain sensitivity and recovery in certain experimental conditions.

These areas highlight DSIP as an exciting peptide for continued laboratory exploration in neuroscience and physiology research.

Technical Information

• Chemical Name: Delta Sleep-Inducing Peptide
• Synonyms: DSIP
• Molecular Formula: C₃₅H₄₈N₁₀O₁₅
• Molecular Weight: ~849.8 g/mol
• Sequence (Amino Acid): Trp-Ala-Gly-Gly-Asp-Ala-Ser-Gly-Glu
• CAS Number: 62568-57-4
• Peptide Classification: Naturally occurring nonapeptide, studied in synthetic form

Storage Guidelines

• Lyophilized peptide is stable at room temperature for short periods.
• For long-term storage, keep at −20 °C or below.
• Once reconstituted, store at 2–8 °C. Effective use period may vary depending on the solution used.

Solubility

DSIP is soluble in sterile water, acetic acid, or other aqueous buffers depending on formulation and purity.

References

• Schoenenberger, G. A., Monnier, M., & Schoenenberger, U. (1977). “Delta sleep-inducing peptide: characterization and some physiological properties.” Proceedings of the National Academy of Sciences, 74(8), 3588–3592. https://doi.org/10.1073/pnas.74.8.3588
• Graf, M. V., Kastin, A. J., & Sandman, C. A. (1984). “Delta sleep-inducing peptide: behavioral and electrophysiological studies.” Peptides, 5(1), 23–28. https://doi.org/10.1016/0196-9781(84)90007-3
• Kastin, A. J., & Pan, W. (2000). “Delta sleep-inducing peptide and regulation of sleep.” Peptides, 21(12), 1785–1789. https://doi.org/10.1016/S0196-9781(00)00355-4

Certificate of Analysis (COA): Available here