MGF (Mechano Growth Factor) is a splice variant of the insulin-like growth factor-1 (IGF-1) gene. It has drawn considerable scientific attention in research exploring cellular repair, growth, and recovery mechanisms. MGF has been studied in laboratory settings for its unique role in initiating muscle repair signaling, setting it apart as an exciting area of peptide research.

Area of Interest

Research into MGF has focused on several key areas:

• Muscle Regeneration: Investigated for its ability to activate satellite cells, which play a central role in skeletal muscle repair and regeneration.
• Tissue Recovery: Explored in preclinical studies for its potential role in enhancing recovery from mechanical stress or injury.
• Neurological Research: Early-stage studies have examined possible protective effects on neurons, particularly under stress conditions.
• Comparison with PEG-MGF: Unlike PEGylated MGF, which has an extended half-life, native MGF is rapidly broken down. Research often compares the two forms to evaluate stability and functional differences.

Together, these research areas position MGF as an important peptide for ongoing study, particularly in models of tissue repair and cellular adaptation.

Technical Information

• Chemical Name: Mechano Growth Factor (IGF-1 splice variant)
• Synonyms: IGF-1 Ec, MGF peptide
• Molecular Formula: C₁₂₁H₂₀₀N₄₂O₃₉S
• Molecular Weight: ~2888 g/mol
• Sequence (Amino Acid): YQPPSTNKNTKSQRRKGSTFEEHK (short peptide fragment)
• Peptide Classification: Endogenous splice variant of IGF-1

Storage Guidelines

• Lyophilized peptide is stable at room temperature for short periods.
• For long-term storage, keep at −20 °C or below.
• Once reconstituted, store at 2–8 °C. Effective use depends on the solution used.

Solubility

MGF is soluble in sterile water, acetic acid, or other aqueous buffers depending on formulation.

References

• Goldspink, G. (2005). "Mechanical signals, IGF-I gene splicing, and muscle adaptation." Physiology, 20(4), 232–238. https://doi.org/10.1152/physiol.00004.2005
• Yang, S. Y., & Goldspink, G. (2002). "Different roles of the IGF-I Ec peptide (MGF) and mature IGF-I in myoblast proliferation and differentiation." FEBS Letters, 522(1-3), 156–160. https://doi.org/10.1016/S0014-5793(02)02918-6
• Qin, L., Chen, Y., Niu, Y., et al. (2013). "IGF-1 Ec (MGF) expression in nervous system of rat and human brain after hypoxia ischemia." Brain Research, 1507, 125–132. https://doi.org/10.1016/j.brainres.2013.02.047

Certificate of Analysis (COA): Available here