Epithalon (Epitalon) is a synthetic tetrapeptide that has been the subject of research for its potential roles in cellular regulation and aging-related pathways. Originally derived from a natural extract known as Epithalamin, Epithalon has been studied in preclinical and laboratory models as an exciting candidate in the field of biogerontology and molecular biology.

Area of Interest

Research into Epithalon has focused on several promising areas:

• Telomerase Activity: Investigated for its ability to influence telomerase expression, a process linked with cellular replication and longevity.
• Oxidative Stress: Studied in models of oxidative damage and antioxidant defense systems.
• Neuroprotection: Preclinical research has explored possible protective effects in age-related neurological studies.
• Aging Models: Examined as part of laboratory investigations into biological markers of aging and lifespan modulation.

Together, these studies highlight Epithalon as a peptide of significant interest in aging and cellular biology research.

Technical Information

• Chemical Name: Ala-Glu-Asp-Gly (synthetic tetrapeptide)
• Synonyms: Epitalon, Epithalamin
• Molecular Formula: C₁₄H₂₂N₄O₉
• Molecular Weight: ~390.35 g/mol
• Sequence (Amino Acid): Ala-Glu-Asp-Gly
• CAS Number: 307297-39-8
• Peptide Classification: Synthetic tetrapeptide derived from natural thymus extract (Epithalamin)

Storage Guidelines

• Lyophilized peptide is stable at room temperature for short periods.
• For long-term storage, keep at −20 °C or below.
• Once reconstituted, store at 2–8 °C. Effective use depends on the solution used.

Solubility

Epithalon is soluble in sterile water, acetic acid, or other aqueous buffers depending on purity and formulation.

References

• Khavinson, V. K., & Malinin, V. V. (2002). “Epithalamin peptide complex regulates melatonin synthesis and structural-functional state of pineal gland.” Neuroendocrinology Letters, 23(Suppl 3), 45–49.
• Khavinson, V., Anisimov, V., & Zavarzina, N. (2003). “Effect of Epitalon on biomarkers of aging, life span, and spontaneous tumor incidence in rats.” Biogerontology, 4(4), 193–202. https://doi.org/10.1023/A:1024902313405
• Khavinson, V. K., Lin’kova, N. S. (2006). “Epitalon regulates expression of telomerase activity in human somatic cells.” Bulletin of Experimental Biology and Medicine, 142(2), 293–296. https://doi.org/10.1007/s10517-006-0338-5

Certificate of Analysis (COA): Available here