GHRP-6 (Growth Hormone Releasing Peptide-6) is a synthetic research peptide belonging to the growth hormone secretagogue family. It has been studied in laboratory and preclinical settings for its ability to stimulate growth hormone release through ghrelin receptor activation. Beyond its central role in hormone pathways, GHRP-6 has generated interest for research into metabolism, appetite regulation, and recovery mechanisms.

Area of Interest

Scientific studies of GHRP-6 have explored several areas of potential interest:

• Growth Hormone Release: Investigated for its activity at the ghrelin receptor, leading to increased growth hormone secretion in animal models.
• Metabolism & Energy Balance: Studied for its potential effects on glucose handling, fat metabolism, and energy regulation.
• Appetite Research: Preclinical work has shown stimulation of appetite, making it an interesting tool in studies of hunger pathways and feeding behavior.
• Tissue Recovery: Considered in the context of wound healing, muscle repair, and systemic recovery due to its growth hormone–linked activity.

Together, these research areas highlight GHRP-6 as an exciting candidate for understanding hormone regulation and its downstream biological effects.

Technical Information

• Chemical Name: Growth Hormone Releasing Peptide-6
• Synonyms: His-D-Trp-Ala-Trp-D-Phe-Lys-NH₂
• Molecular Formula: C₄₆H₅₆N₁₂O₆
• Molecular Weight: 873.01 g/mol
• Sequence (Amino Acid): His-D-Trp-Ala-Trp-D-Phe-Lys-NH₂
• CAS Number: 87616-84-0
• Peptide Classification: Synthetic hexapeptide; ghrelin receptor agonist

Storage Guidelines

• Lyophilized peptide is stable at room temperature for short periods.
• For long-term storage, keep at −20 °C or below.
• Once reconstituted, store at 2–8 °C. Effective use depends on the solution used.
  

Solubility

GHRP-6 is soluble in sterile water, acetic acid, or other aqueous buffers depending on purity and formulation.

References

• Bowers, C. Y., Momany, F. A., Reynolds, G. A., et al. (1984). “On the in vitro and in vivo activity of a new synthetic hexapeptide that acts as a GH secretagogue.” Endocrinology, 114(5), 1537–1545. https://doi.org/10.1210/endo-114-5-1537
• Kojima, M., Hosoda, H., Date, Y., et al. (1999). “Ghrelin is a growth-hormone-releasing acylated peptide from stomach.” Nature, 402, 656–660. https://doi.org/10.1038/45230
• Smith, R. G., Van der Ploeg, L. H., Howard, A. D., et al. (1997). “Peptidomimetic regulation of growth hormone secretion.” Endocrine Reviews, 18(5), 621–645. https://doi.org/10.1210/edrv.18.5.0319

Certificate of Analysis (COA): Available here