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IGF1-LR3 (Long R3 Insulin-like Growth Factor-1) is a synthetic, recombinant analogue of human insulin-like growth factor 1 (IGF-1). Engineered with an arginine substitution at position 3 and a 13-amino-acid extension at the N-terminus, IGF1-LR3 is designed to have a markedly reduced affinity for IGF-binding proteins (IGFBPs). As a research peptide, it has become an essential tool in laboratory and in vitro environments for the study of cellular proliferation, receptor signaling, and stem cell maintenance. While not approved for human or veterinary use, IGF1-LR3 continues to be heavily utilized in rigorous academic and preclinical research settings.

Area of Interest

Research on IGF1-LR3 has focused on several promising areas:

• Cellular Proliferation & Stem Cell Research: Explored extensively in cell culture models for its ability to support the maintenance, expansion, and differentiation of pluripotent and mesenchymal stem cells in vitro.
• Receptor Signaling Pathways: Studied for its role as a potent agonist of the IGF-1 receptor (IGF1R), allowing researchers to map downstream signaling networks, including the PI3K/Akt and MAPK/ERK cascades.
• Apoptosis & Cellular Survival: Investigated in preclinical assays for its potential to inhibit cellular apoptosis and promote survival in various isolated tissue models.
• Metabolic Function: Research includes evaluating its influence on cellular glucose metabolism and targeted lipolytic pathways in controlled environments.

Together, these areas position IGF1-LR3 as a critical component in biomedical discovery, offering robust stability for advanced laboratory applications. Further context on peptide signaling pathways can be found in our Knowledge Hub.

Technical Information

• Chemical Name: Long Arg3 Insulin-like Growth Factor-1
• Synonyms: IGF-1 LR3, LR3-IGF-1, Long R3 IGF-I
• Molecular Formula: C₄₀₀H₆₂₅N₁₁₁O₁₁₅S₉
• Molecular Weight: 9117.6 g/mol (~9.1 kDa)
• Sequence (Amino Acid): MFPAMPLSSL FVNGPRTLCG AELVDALQFV CGDRGFYFNK PTGYGSSSRR APQTGIVDEC CFRSCDLRRL EMYCAPLKPA KSA
• CAS Number: 946870-92-4
• Peptide Classification: Synthetic recombinant analogue of human IGF-1

Storage Guidelines

• Lyophilized peptide is stable at room temperature for short periods.
• For long-term storage, keep at −20°C or below.

• Once reconstituted, store at 2–8 °C. Effective use depends on the solution used.

Solubility

IGF1-LR3 is soluble in Bacteriostatic water, acetic acid, or other aqueous buffers depending on purity and formulation.

References

• Tomas, F. M., Lemmey, A. B., Read, L. C., & Ballard, F. J. (1996). "Superior potency of infused IGF-I analogues which bind poorly to IGF-binding proteins is maintained when administered by injection." Journal of Endocrinology, 150(1), 77–84. https://doi.org/10.1677/joe.0.1500077
• Youssef, A., Aboalola, D., & Han, V. K. (2017). "The Roles of Insulin-Like Growth Factors in Mesenchymal Stem Cell Niche." Stem Cells International, 2017, 9453108. https://doi.org/10.1155/2017/9453108
• Werner, H. (2023). "The IGF1 Signaling Pathway: From Basic Concepts to Therapeutic Opportunities." International Journal of Molecular Sciences, 24(19), 14882. https://doi.org/10.3390/ijms241914882

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