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NAD⁺ (Nicotinamide Adenine Dinucleotide) is a coenzyme naturally found in all living cells and has become a central focus in modern biological research. Exciting preclinical studies have explored its potential roles in energy metabolism, cellular repair, and pathways linked to healthy aging. As a research peptide, NAD⁺ offers laboratories a valuable tool to investigate fundamental processes of life at the molecular level.

Area of Interest

Research into NAD⁺ has highlighted several key areas of interest:

• Energy Metabolism: Studied for its role in mitochondrial efficiency and ATP production.
• Cellular Repair: Investigated for involvement in DNA repair and cellular stress responses.
• Oxidative Stress: Explored in models of redox balance and protection from cellular damage.
• Aging & Longevity: Preclinical work has examined links between NAD⁺ levels and healthy aging pathways.
• Neurobiology: Considered in research on synaptic plasticity and neuronal resilience.

Together, these studies position NAD⁺ as an exciting molecule of high relevance across multiple disciplines of biomedical research.

Technical Information

• Chemical Name: Nicotinamide Adenine Dinucleotide (oxidized form)
• Synonyms: β-Nicotinamide adenine dinucleotide, DPN, Coenzyme I
• Molecular Formula: C₂₁H₂₇N₇O₁₄P₂
• Molecular Weight: 663.43 g/mol
• CAS Number: 53-84-9
• PubChem CID: 5893
• Peptide Classification: Pyridine nucleotide coenzyme – oxidized form

Storage Guidelines

• Lyophilized NAD⁺ is stable at −20°C for long-term storage.
• Reconstituted solutions should be stored at 2–8°C and used promptly.

Solubility

NAD⁺ is soluble in sterile water and common aqueous buffers.

References

• Bogan, K. L., & Brenner, C. (2008). “Nicotinic acid, nicotinamide, and nicotinamide riboside: A molecular evaluation of NAD⁺ precursor vitamins in human nutrition.” Annual Review of Nutrition, 28, 115–130. https://doi.org/10.1146/annurev.biochem.77.061606.102346
• Verdin, E. (2015). “NAD⁺ in aging, metabolism, and neurodegeneration.” Science, 350(6265), 1208–1213. https://doi.org/10.1126/science.aac4854
• Canto, C., & Auwerx, J. (2012). “NAD⁺ as a signaling molecule modulating metabolism.” Cold Spring Harbor Symposia on Quantitative Biology, 76, 291–298. https://doi.org/10.1101/sqb.2011.76.010439

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