VIP (Vasoactive Intestinal Peptide) is a 28-amino acid neuropeptide that functions as a neuromodulator and neurotransmitter. It is widely distributed in the central and peripheral nervous systems, particularly within the gut-brain axis. Preclinical research has identified VIP as a critical regulator of circadian rhythms (via the Suprachiasmatic Nucleus) and a potent modulator of the immune system. Studies focus on its ability to shift immune responses from pro-inflammatory (Th1) to anti-inflammatory (Th2) pathways. Supplied as a lyophilized powder strictly for laboratory research.

Area of Interest

Research on VIP has focused on several critical physiological pathways:

• Circadian Rhythm Regulation: Investigated for its role in the Suprachiasmatic Nucleus (SCN), where it helps synchronize the body's internal clock and regulate metabolic timing.
• Immune Modulation & Inflammation: Studies examine its ability to downregulate pro-inflammatory cytokines (such as TNF-α and IL-6) and promote regulatory T-cell function.
• Gut-Brain Axis: Research focuses on its maintenance of intestinal epithelial barrier integrity ("Tight Junctions") and its role in gut motility and secretion.
• Neuroprotection: Preclinical models explore its potential neurotrophic effects, protecting neurons from toxic insults and supporting synaptic plasticity.

These properties make VIP a primary reagent for laboratories investigating CIRS (Chronic Inflammatory Response Syndrome), autoimmune models, and circadian biology.

Technical Information

• Chemical Name: Vasoactive Intestinal Peptide (VIP)
• Synonyms: VIP-28
• Molecular Formula: C₁₄₇H₂₃₈N₄₄O₄₂S
• Molecular Weight: 3325.8 g/mol
• Sequence: His-Ser-Asp-Ala-Val-Phe-Thr-Asp-Asn-Tyr-Thr-Arg-Leu-Arg-Lys-Gln-Met-Ala-Val-Lys-Lys-Tyr-Leu-Asn-Ser-Ile-Leu-Asn-NH2
• CAS Number: 37221-79-7
• Peptide Classification: Neuropeptide / Glucagon/Secretin Family

Storage Guidelines

• Lyophilized peptide is stable at room temperature for several weeks.
• For long-term storage, keep at −20°C or below.

• Once reconstituted, store at 2–8 °C. VIP is susceptible to oxidation; avoid vigorous shaking.

Solubility

VIP is soluble in sterile water, saline, or bacteriostatic water. Due to its methionine content, avoid excessive exposure to air after reconstitution to prevent oxidation.

References

• Delgado, M., & Ganea, D. (2003). “Vasoactive intestinal peptide: a neuropeptide with pleiotropic immune functions.” Amino Acids, 25(3-4), 331–371. https://doi.org/10.1007/s00726-003-0019-2
• Harmar, A. J., et al. (2012). “Pharmacology and functions of receptors for vasoactive intestinal peptide and pituitary adenylate cyclase-activating polypeptide.” Pharmacological Reviews, 64(2), 328–361. https://doi.org/10.1124/pr.110.003806
• Vosko, A. M., Colwell, C. S., & Waschek, J. A. (2007). “Vasoactive intestinal peptide regulation of circadian rhythms.” Experimental Neurology, 205(1), 26–31. https://doi.org/10.1016/j.expneurol.2007.02.007
• Pozo, D., et al. (2000). “Immunobiology of vasoactive intestinal peptide (VIP).” Immunology Today, 21(1), 7–11. https://doi.org/10.1016/S0167-5699(99)01533-5

Certificate of Analysis (COA): Available here