TB-500

Certificate of Analysis (COA): See Images

TB-500 is the synthetic peptide fragment of Thymosin Beta-4, a naturally occurring protein found in most human and animal cells. As a research peptide, TB-500 has been studied extensively in laboratory and preclinical models for its potential roles in tissue repair, cellular migration, and angiogenesis. It has gained significant attention within the scientific community as an exciting area of ongoing research.

Area of Interest

Research into TB-500 has focused on several promising areas:

• Tissue Repair: Explored for its ability to promote cellular migration and regeneration in models of muscle, tendon, and ligament injury.
• Angiogenesis: Studied for its role in the formation of new blood vessels, a process critical in wound healing and recovery from ischemic damage.
• Anti-Inflammatory Pathways: Preclinical models suggest possible modulation of inflammatory responses, making it a candidate for research in chronic injury models.
• Neurological Studies: Some studies have evaluated its potential influence on nerve repair and regeneration, although evidence remains early-stage.

Together, these research areas highlight TB-500 as a peptide of high interest, reflecting its potential as a versatile and exciting candidate in laboratory settings.

Technical Information

• Chemical Name: Thymosin Beta-4 
• Synonyms: TB-500, Tβ4, Thymosin β4
• Molecular Formula: C₂₁₂H₃₅₀N₅₆O₇₈S
• Molecular Weight: ~4963 g/mol 
• Sequence (Amino Acid): Ac-Ser-Asp-Lys-Pro-Asp-Met-Ala-Glu-Ile-Glu-Lys-Phe-Asp-Lys-Ser-Lys-Leu-Lys-Lys-Thr-Glu-Thr-Gln-Glu-Lys-Asn-Pro-Leu-Pro-Ser-Lys-Glu-Thr-Ile-Glu-Gln-Glu-Lys-Gln-Ala-Gly-Glu-Ser
• CAS Number: 77591-33-4
• Peptide Classification: Synthetic human Thymosin Beta-4 protein

Storage Guidelines

• Lyophilized peptide is stable at room temperature for short periods.
• For long-term storage, keep at −20°C or below.

• Once reconstituted, store at 2–8 °C. Effective use depends on the solution used.

Solubility

TB-500 is soluble in sterile water, acetic acid, or other aqueous buffers depending on purity and formulation.

References

• Goldstein, A. L., Hannappel, E., & Kleinman, H. K. (2005). "Thymosin beta4: actin-sequestering protein moonlights to repair injured tissues." Trends in Molecular Medicine, 11(9), 421–429. https://doi.org/10.1016/j.molmed.2005.07.002
• Philp, D., Badamchian, M., Scheremeta, B., et al. (2003). "Thymosin beta4 and angiogenesis: initiation of new blood vessel growth." Annals of the New York Academy of Sciences, 1002, 168–177. https://doi.org/10.1196/annals.1283.018
• Malinda, K. M., Sidhu, G. S., Mani, H., et al. (1999). "Thymosin beta4 accelerates wound healing." Journal of Investigative Dermatology, 113(3), 364–368. https://doi.org/10.1046/j.1523-1747.1999.00705.x